Caroli disease and the central dot sign

Diffuse-Type Caroli Disease with Characteristic Central Dot Sign Complicated by Multiple Intrahepatic and Common Bile Duct Stones

Caroli disease (CD) is a rare congenital malformation of the liver characterized by non-obstructive, segmental, cystic dilatation of the intrahepatic bile ducts (IHDs). The clinical course is usually asymptomatic for the first 5-20 years, and symptoms may seldom occur throughout the patient's life. Bile stagnation leads to recurrent episodes of cholangitis, stone formation, or liver abscesses, ...

Caroli disease.

Caroli disease is a rare autosomal recessive disorder characterized by multiple segmental communicating dilatations of the intrahepatic bile ducts affecting all or part of the liver that is often associated with renal disorders. It occurs in 2 forms: the rare isolated variety (type I) characterized by recurrent episodes of cholangitis and absence of periportal fibrosis and the more common varie...

Liver Transplantation for Caroli Disease

Caroli disease is a rare congenital disorder characterized by multifocal, segmental dilatation of intrahepatic bile ducts. Patients with Caroli disease who have recurrent bouts of biliary infection, particularly those who also have complications related to portal hypertension may require liver transplantation. In liver transplant ward of Shiraz University of Medical Science we had 4 patients wi...

Hepatic cirrhosis caused by Caroli disease.

Epithelial dysplasia in Caroli ' s disease

SIR, -The comments of Drs Colombel, Janin, and Torpier are of interest. We agree that the immune processes which may contribute to the mucosal lesion of coeliac disease may be multifactorial. The eosinophil is a major component of the inflammatory infiltrate in coeliac disease, although this is frequently not emphasised in descriptions of the lesion. We have recently produced additional evidenc...